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Barbiturates appear to reinforce the metabolism of exogenous corticosteroids possibly through the induction of hepatic microsomal enzymes. People stabilized on corticosteroid therapy may need dosage adjustments if barbiturates are additional to or withdrawn from their dosage regimen.

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Caution needs to be exercised whenever a barbiturate is administered into a nursing lady get more info since compact quantities of barbiturates are excreted within the milk.

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